3/18/2024 0 Comments Dorsal lip vs blastopore lip![]() The dorsal lip refers to the section of tissue located at the site of the first invagination in the developing pregastula and is understood to act as both the neural inducer in the early embryo as well as the overall organizer of the entire body axis. ![]() One such candidate gene, noggin, is sufficient for rescuing development of irradiated embryos when its mRNA is injected (C). Establishment of cDNA libraries from extracted dorsal lip mRNA identified candidate genes that may be responsible for neural induction. Injection of extracted mRNA from the dorsal lip into irradiated Xenopus embryos rescued neural induction and overall development demonstrating there is a genetic basis of neural induction (B). Figure 1: Mangold's dorsal lip transplant experiment in Xenopus demonstrated that a transplanted dorsal lip could induce the formation of a double axis in the new host embryo, solidifying the dorsal lip's sufficiency in neural induction (A). It is particularly important for its role in neural induction through the default model, where signaling from the dorsal lip protects a region of the epiblast from becoming epidermis, thus allowing it to develop to its default neural tissue. The dorsal lip is formed during early gastrulation as folding of tissue along the involuting marginal zone of the blastocoel forms an opening known as the blastopore. The dorsal lip of the blastopore is a structure that forms during early embryonic development and is important for its role in organizing the germ layers.
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